During the 2021 and 2022 seasons Sam Mustipher played almost every offensive snap for the Bears (he missed 13 in 2022). According to PFF grade he was the 30th ranked starting center in 2021.
Mustipher had a big problem with blown blocks in 2021 relative to other starting centers; he allowed 29. For comparison Creed Humphrey (a rookie) allowed seven. Lloyd Cushenberry allowed 22.
Mustipher improved in 2022. He moved from 30th to 18th ranked by PFF overall grade.
| Rank | Center | 2022 PFF grade |
| 1 | Creed Humphrey | 89. |