West Ham boss David Moyes says several players are doubtful through illness.
Moyes didn't name those players but Mohammed Kudus, Vladimir Coufal and Edson Alvarez all missed out in midweek and may need to be assessed.
This game is expected to come too soon for Michail Antonio, who is nursing a knee injury, while Jarrod Bowen is doubtful with a similar issue.
Crystal Palace midfielder Cheick Doucoure faces a lengthy spell on the sidelines after injuring his Achilles.
Eberechi Eze is absent after injuring his ankle last weekend.
Rob Holding, Jesurun Rak-Sakyi and Dean Henderson are sidelined but James Tomkins may come back into contention after recovering from a calf problem.