It has been 27 years since the Eagles last recorded a league victory over Manchester United, marking their longest wait for a win against any other team they have faced since who still play in the top two tiers of English football.
Here, we take a look back at their six previous league wins against the Red Devils, in the hope that the current squad can make it lucky number seven this weekend!
14th February 1925
PALACE 2-1 MAN UTD
The first-ever meeting between the sides at the newly-built Selhurst Park saw the Glaziers record their maiden victory over United at the sixth attempt, thanks to a pair of goals by Welshman Tom Hoddinott [pictured above] with Arthur Lochhead responding for the visitors.