Manchester United will face Liverpool in a pre-season friendly in Thailand in July before facing Crystal Palace in Australia seven days later.
The Old Trafford club will take on Jurgen Klopp's side at the Rajamangala stadium in Bangkok on 12 July.
They will then take on Melbourne Victory at the 100,000-seat Melbourne Cricket Ground on 15 July and face Palace at the same venue on 19 July.
Clubs have not been on pre-season tours in recent years because of Covid-19.
"It has been two years since the club has been able to travel on an international pre-season tour, so we can't wait to get going this summer and reconnect with our fans in south-east Asia and Australasia," Manchester United chief operating officer Collette Roche said.