Luton will assess Issa Kabore, who suffered a head injury playing for Burkina Faso.
Chieo Ogbene missed the Republic of Ireland's recent matches with an ankle injury and is also being monitored.
Crystal Palace defender James Tomkins, who hasn't played since August, could return from a calf injury.
Jesurun Rak-Sakyi and Nathan Ferguson remain sidelined with hamstring injuries, while goalkeeper Dean Henderson is out with a thigh problem.
MATCH FACTS
Head-to-head
- This is the first meeting between the sides since February 2007.
- Four of the six top-flight encounters have ended 1-1, including both games when the sides last met in the top tier in 1991-92.