Crystal Palace may be without centre-back Marc Guehi, who reportedly suffered an ankle injury against Everton on Thursday despite completing 90 minutes.
Manchester United interim manager Ralf Rangnick will take charge of his final match, with successor Erik ten Hag set to watch from the stands.
Paul Pogba is still sidelined by a calf issue.
Jadon Sancho and Phil Jones are doubtful with unspecified injuries, while Luke Shaw's availability is uncertain after he missed training following the birth of his second child.
Rangnick added on Friday that "quite a few players" would definitely be absent at Selhurst Park but said "I don't want to name all those names right now".