Crystal Palace forward Jordan Ayew should overcome the bang on the hip that caused him to come off during last week's defeat by Tottenham.
Eberechi Eze was also substituted against Spurs but manager Oliver Glasner suggested it was a precaution given his recent injury history.
Luton defender Amari'i Bell is a doubt after coming off in just the sixth minute against Aston Villa last week.
Head coach Rob Edwards will give an update on his squad on Friday.
MATCH FACTS
Head-to-head
- Luton won the reverse fixture 2-1 and could complete only their fourth league double over Crystal Palace, and their first since the 2005-06 Championship.