Beyond Santana's two homers -- one off Bartolo Colon in the fourth and another off Dietrich Enns in the ninth -- Jason Kipnis, Edwin Encarnacion and Austin Jackson each homered to help back Salazar's effort. Three solo home runs came against the 44-year-old Colon, who walked four and allowed seven hits in his five innings.
Jackson broke the game open in the seventh with a three-run homer off Twins reliever Buddy Boshers.