The Cleveland Browns will close out the month of November when they host the San Francisco 49ers in Week 13 of the 2025 NFL season.
The series between the Browns and 49ers dates back to the days of the All-America Football Conference, with the first meeting coming on October 27, 1946. Cleveland holds a 20-10 advantage over San Francisco, which includes a title game victory in 1949.
The Browns have also been competitive against the 49ers since 1999, with Cleveland holding a 4-2 edge, including wins in two of the last three meetings.