Will the Clemson defense be able to take advantage of the Isaac Brown injury?

Fansided | November 13, 2025

Louisville star running back Isaac Brown is out with a leg injury. After he ran for over 150 yards in the matchup last season, will Clemson be able to capitalize on his absence?

Nov 8, 2025; Clemson, South Carolina, USA; Clemson Tigers defensive coordinator Tom Allen communicates with players in the game against the Florida State Seminoles during the second quarter at Memorial Stadium. Mandatory Credit: Ken Ruinard - GREENVILLE NEWS-USA TODAY Network via Imagn Images | Ken Ruinard - GREENVILLE NEWS-USA TODAY Network via Imagn Images

This Friday night, Clemson will be on the road to take on Louisville.