Sharpe homered twice and drove in all three Clemson runs but the rest of the Clemson offense went cold as South Alabama salvaged the finale of the three-game season-opening series with a 4-3 victory Saturday evening at Doug Kingsmore Stadium.
Clemson managed just six hits.
Clemson won the first game of the doubleheader Saturday 7-2 to clinch the series.
Neither team mustered much offense through the first three innings, but freshman Tiger starter Justin Wrobelski ran into trouble in the fourth.
A single and a hit batter put runners at first and second to start the inning.