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Opening Odds: Clemson begins Duke week as a small home favorit

Clemson had a five-game winning streak over the Blue Devils halted in the last meeting.

Oct 18, 2025; Clemson, South Carolina, USA; Clemson Tigers wide receiver T.J. Moore (1) celebrates his 32-yard touchdown catch against the Southern Methodist Mustangs during the second quarter at Memorial Stadium. Mandatory Credit: Ken Ruinard-GREENVILLE NEWS-USA TODAY Network via Imagn Images | Ken Ruinard-GREENVILLE NEWS-USA TODAY Network via Imagn Images

The Clemson Tigers are just a tad over a field-goal favorite over the Duke Blue Devils to start the week.

The home team at Memorial Stadium for Saturday’s noon game opened as a 2.