A complete guide to the Clemson vs. No. 19 Louisville ACC football game on Friday, Nov. 14, 2025. Get stats, series history, betting odds, and a full preview of the high-stakes conference finale.
A resurgent Clemson team playing for its postseason life travels to face No. 19 Louisville on Friday night in a high-stakes ACC finale with major implications for both programs.
For Clemson (4-5, 3-4 ACC), a 26-year streak of finishing .500 or better in conference play is on the line.