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The Clemson Insider · Aug 30, 2025

College Gameday Analysts Give Their Picks for Clemson-LSU

The College GameDay selections are in for Week 1, including the top-10 showdown at Clemson’s Death Valley.

ESPN’s College GameDay crew has made their picks for tonight’s highly anticipated season opener between No. 4 Clemson and No. 9 LSU at Memorial Stadium.

Clemson comes in as a 4.5-point favorite on the spread for the game, which is set to kick off at 7:30 p.m. and will be televised on ABC.

You can see the picks from the College GameDay analysts below:

Desmond Howard: Clemson

“Blake Baker, the defensive coordinator for LSU, he wants to put a lot of pressure on Cade Klubnik. I think that’s gonna burn him. I’m going with Clemson over LSU.”

Nick Saban: Clemson

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