The Clemson Insider · Sep 20, 2025
College Gameday Analysts Give Their Picks for Clemson-Cuse
The College GameDay selections are in for Week 4 of the college football season.
ESPN’s College GameDay crew has made their picks (against the spread) for today’s matchup between Clemson (1-2) and Syracuse (2-1) at Death Valley.
Clemson has won six straight games overall against Syracuse.
The Tigers are 10-2 all-time against Syracuse but 5-0 against the Orange in Death Valley. This year’s game marks Syracuse’s first visit to Memorial Stadium since 2022, a 27-21 win in which then-freshman Cade Klubnik entered in reserve at quarterback and helped the Tigers overcome an 11-point fourth quarter deficit in the victory.