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Clemson-Syracuse betting preview: Despite ATS struggles, Tigers remain big favorite

Related Topics: Clemson, Syracuse

No longer ranked and off to a 1-2 start, the Clemson Tigers are still a large favorite against the Syracuse Orange on Saturday at noon inside Memorial Stadium.

Dabo Swinney’s squad hasn’t covered a spread this season, and they’ll need an effort they haven’t shown in 2025 to get past the 17.5-point line at DraftKings. FanDuel lists Clemson at -16.5 heading into kickoff.

With that big of a spread, winning should be a formality. Clemson’s implied odds, based on the -850 moneyline, to win the game are nearly 90%. However, winning hasn’t been easy for the Tigers.