Clemson is an underdog entering its road game against Louisville on Friday night.
The Cardinals (7-2, 4-2 ACC) open as a 3.5-point favorite over the Tigers (4-5, 3-4 ACC), according to FanDuel Sportsbook.
The contest is set to kick off at 7:30 p.m. and will be televised on ESPN.
The Cardinals earned their first win against the Tigers in series history last season with a 33-21 win at Clemson’s Memorial Stadium. However, Clemson remains 4-0 in road games at Louisville, including most recently a 30-24 victory in 2021 in which the Tigers held the Cardinals out of the end zone on four straight downs from the Clemson 2-yard line in the final minute for the win.