Third-ranked Clemson showed up to play after a three-week hiatus and rolled into the halftime break with a 38-10 lead over Pittsburgh.
The Tigers regained a couple of key pieces in the heart of the defense in James Skalski and Tyler Davis. However, they were depleted in the secondary with the absence of safeties Lannden Zanders and Jaylen Phillips as well as cornerback Sheridan Jones.
Onlookers would be hard pressed to notice the missing players as Clemson intercepted three Kenny Pickett passes in the first quarter.
Freshman Malcom Greene intercepted Pickett with 12:32 to play in the first quarter and returned the pass eight yards to the Pitt 16 and set up a touchdown pass from Trevor Lawrence to E.