Clemson jumped on the long ball with two outs in a four run third inning to surge ahead of Louisville 4-1.
Bryce Teodosio led off the bottom of the third with a double down the left field line but a strike out by Elijah Henderson and James Parker put the top of the lineup at the plate with two outs.
Sam Hall drew a walk in a full count before Logan Davidson hit a three-run bomb over the grandstand in right field to give the Tigers a 3-1 lead.
Kyle Wilkie lofted a flyball to right-center on the following pitch that stuck out for a solo home run and moved Clemson’s lead to 4-1 entering the fourth inning and putting all the momentum in the Tiger dugout.