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Fansided · Nov 14, 2025

5 keys to victory: Clemson at Louisville

Clemson (4-5) is a road underdog against #19 Louisville (7-2). To win, Cade Klubnik must stay hot, the defense must travel, and they must conquer a massive statistical mismatch.

Louisville v Clemson | Isaiah Vazquez/GettyImagesThe Clemson Tigers (4-5) are riding high after a season-saving 24-10 defensive domination of Florida State. But there's no time to celebrate. Dabo Swinney's team faces a short week and a hostile Friday night environment against the #19 Louisville Cardinals (7-2), a team that is statistically built to exploit Clemson's biggest weaknesses.

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