You don't always need to consider benching studs in tough matchups, but your fringe starters may be impacted enough to consider a replacement. These players or units should be considered in that group for Week 3.
I'm not here to tell you if and when Christian McCaffrey or DeAndre Hopkinshile it's good to know the strength of matchups for all of your players, it's much more valuable in relation to the fringe starters and high-end bench players than it is for your studs. Matchups should be one of the final components in making roster decisions, whether drafting for season-long strength of schedule or making a start/sit decision.