No team in the eight-year history of the American Athletic Conference (AAC) has ever played five straight road games.
Cincinnati will be the first on Thursday.
The University of Cincinnati men's basketball team, riding back-to-back victories at Temple and Tulane, will have its toughest test since returning from a 25-day pause due to COVID-19 issues.
The Bearcats (5-7, 3-4 AAC) will face a Memphis Tigers team that is long, athletic, deep and has won three straight.
"You just can't replicate their length and athleticism in practice," UC Head Coach John Brannen said.