In the second game of the season, St. Louis Browns center fielder Sam West went 6-for-6 (five singles, a double) against White Sox ace Ted Lyons. West would go on to hit .300 that year, as well as be named to the first-ever AL All-Star team.
Despite West’s efforts, the Browns still lost, 11-7.
1965
The White Sox turned the tide so to speak from 1964, beating the Orioles in Baltimore on Opening Day, 5-3. They lost to the same club to open the 1964 season at Comiskey Park — by the exact margin.