Abreu drove in a run with a single in the first inning. He had a two-run single during a four-run third inning and added a double in the sixth to lead the Sox to the win in the seven-inning game.
Right fielder Jack Lamb hit a two-run home run to right-center in the third against Orioles starter Matt Harvey to make it 5-1. Third baseman Yoán Moncada hit a two-run homer against reliever Shawn Armstrong in the sixth to give the Sox a 7-4 lead. Tim Anderson doubled, walked and scored twice.
Sox starter Dallas Keuchel (4-1) allowed four runs on eight hits with two strikeouts and one walk in five innings.