The Chicago White Sox will begin the 2022 season March 31 with a home game against the Minnesota Twins. Meanwhile, the Cubs kick off next season on the road in Cincinnati to face the Reds.
In addition to playing the Cubs (May 3-4 at Wrigley Field, May 28-29 at Guaranteed Rate Field), the Sox will have interleague games against the National League West. The Cubs will face American League East teams.
The Sox play the Los Angeles Dodgers (June 7-9 at Guaranteed Rate Field), San Francisco Giants (July 1-3 at Oracle Park), Colorado Rockies (July 26-27 at Coors Field, Sept.