The Chicago White Sox struggle to win in Kansas City, Minneapolis, and Toronto. The team was also terrible in Oakland before the A's moved out of that market.
The Chicago White Sox have been terrible on the road this season, with an 18-44 record when they're away from Rate Field. The Colorado Rockies are the only team with a worse record away from home.
An interesting note is that White Sox hitters have a slash line on the road that is just a few percentage points below the home slash line.