Amidst ongoing broadcast discussions with the likes of ESPN, Apple, Netflix and NBC, MLB commissioner Rob Manfred talked about the potential for expansion and league-wide realignment, mentioning one of the factors at play being the considerations of the league's broadcast partners.
Top markets for expansion include Nashville and Charlotte, which would take the total from 30 to 32 teams, allowing MLB to evenly distribute the teams across two leagues or conferences with four divisions of four teams apiece. Again, there's no hard evidence that's how they'd do it, but it's at least possible.
For one generation of Chicago Cubs fans, the National League Central is all they've ever known.