West Ham could hand debuts to new signings Edson Alvarez and James Ward-Prowse.
Alvarez missed out against Bournemouth last week as he was short of match fitness.
Chelsea captain Reece James is set for a spell on the sidelines after injuring his hamstring.
Benoit Badiashile, Marcus Bettinelli, Armando Broja, Trevoh Chalobah, Wesley Fofana and Christopher Nkunku all remain out.
MATCH FACTS
Head-to-head
- West Ham's only win in their last six Premier League matches against Chelsea was a 3-2 victory at the London Stadium in December 2021.