Spurs are without a recognised left-back ahead of a huge London derby, with Danny Rose suspended and Ben Davies injured.
"We can play Jan [Vertonghen], we can play Kevin Wimmer, maybe we’ll use Kieran Trippier on the left. We’ll see. We have two training sessions ahead to decide what is best for the team," manager Mauricio Pochettino said.
Elsewhere, Erik Lamela and Toby Alderweireld are also sidelined with injuries. Chelsea have won six successive Premier League games and have not conceded any goals during this time. In their last three league matches, the Blues have only allowed their opponents two shots on target in total, while attempting 19 themselves.