The defender only returned to the team for Wednesday's Champions League semi-final, second leg defeat to Chelsea but now looks set for another spell on the sidelines.
Real host Sevilla on Sunday evening as they attempt to reel in Atletico Madrid at the top of LaLiga.
Real Madrid captain Sergio Ramos has been diagnosed with hamstring tendonitis
It is just the latest injury setback for the veteran Real Madrid defender this season
Atletico have a two-point advantage entering the weekend's fixtures but they travel to third-placed Barcelona on Saturday afternoon with the outcome pivotal to the title outcome.