Manchester United midfielder Mason Mount is doubtful to face his former club because of a calf problem.
Tyrell Malacia, Casemiro, Jonny Evans, Lisandro Martinez, Christian Eriksen and Amad Diallo are set to miss out.
Chelsea welcome back Reece James and Marc Cucurella from suspension but Conor Gallagher serves a one-game ban.
Noni Madueke and Lesley Ugochukwu are both nursing injuries, meaning the visitors may be without 10 players for the trip to Old Trafford.
MATCH FACTS
Head-to-head
- Manchester United are unbeaten in 11 league games against Chelsea since losing 1-0 at Stamford Bridge in November 2017 (W4, D7).