Newcastle United's Anthony Gordon and Nick Pope have withdrawn from England's squad to face Serbia and Albania.
While Gordon was ruled out of the Magpies' trip to Brentford with a hip injury, Pope had to be withdrawn in the second-half after suffering concussion.
Eddie Howe hinted post-match that the duo would be ruled out of international duty and now their withdrawals have been confirmed by the FA.
Chelsea's Trevoh Chalobah and Man City's reserve goalkeeper James Trafford have been called up by Thomas Tuchel ahead of Thursday's World Cup Qualifier against Serbia at Wembley.