Liverpool will aim to stay on course for a quadruple in the Carabao Cup final, while Chelsea bid for their first domestic trophy in six years.
Currently leading the Premier League by four points and into the Europa League last 16 and FA Cup fifth round, the Reds can win four trophies this season.
"We'll go for it," said Liverpool's assistant manager Pep Lijnders.
"It's a special game. Special games need special performances so we have to focus on the performance."
With Lijnders and manager Jurgen Klopp set to leave Anfield this summer, Liverpool fans are eager for them to enjoy a triumphant send-off having already won six major honours since they arrived in 2015.