Chelsea's Ben Chilwell is likely to be absent after falling ill while recovering from a knee injury.
Defenders Trevoh Chalobah and Malo Gusto should be fit to play, while Robert Sanchez may also return.
Manchester United centre-backs Victor Lindelof and Lisandro Martinez are the latest two players to be ruled out.
Amad Diallo returns from suspension following his red card for celebrating the dramatic winner against Liverpool in the FA Cup quarter-final.
MATCH FACTS
Head-to-head
- Chelsea are winless in the past 12 Premier League meetings (D7, L5). It's their longest run without a league victory against Manchester United.