Chelsea duo Mason Mount and Reece James are both expected to miss the rest of the season due to respective pelvic and hamstring injuries.
Kai Havertz is unavailable to face Brentford because of an ongoing knee injury but he is expected to feature again in this campaign.
Brentford midfielder Christian Norgaard misses out after he was forced off against Aston Villa on Saturday.
Thomas Strakosha is also absent due to injury but Kevin Schade is available.
CHRIS SUTTON'S PREDICTION
Frank Lampard has lost all four of his games as interim Chelsea manager.