Henrikh Mkhitaryan will have to wait to make his Arsenal debut having already featured for Manchester United in the previous round of the Carabao Cup against Bristol City.
The first leg of the tie ended in a 0-0 draw at Stamford Bridge, and was the last appearance of Alexis Sanchez in an Arsenal shirt before his move to Manchester United.
Chelsea come into the game on the back of a 4-0 thrashing of Brighton at the Amex, while the Gunners put Crystal Palace to the sword at home on Saturday.