Manchester United centre-back Eric Bailly will be out for around two months after suffering a knee injury in the defeat by Chelsea last weekend.
Chris Smalling is expected to overcome a knock to play, but Wayne Rooney and Marcus Rashford are both doubtful.
Burnley striker Andre Gray is available again after serving a four-match ban for homophobic social media posts.
George Boyd has recovered from a knee injury, but Steven Defour is "touch and go" after a hamstring problem.
MOTD COMMENTATOR'S NOTES
Jonathan Pearce: "Jose Mourinho says he risks losing his "Special One" tag if he fails to deliver silverware to United.