Burnley captain Ben Mee has been released after 11 years with the club.
He twice helped the team win promotion to the Premier League and ended last season assisting caretaker coach Mike Jackson as they were relegated.
Aaron Lennon, Phil Bardsley, Dale Stephens, Erik Pieters and James Tarkowski are also leaving.
England international Tarkowski, 29, is in talks to join Everton.
The Turf Moor side are in talks with midfielder Jack Cork, 32, and striker Matej Vydra, 29, about extending their deals.
Under-23 players Joel Mumbongo, Richard Nartey, Anthony Glennon, Ethen Vaughan, Sam Unwin, Anthony Gomez Mancini, Calen Gallagher-Allison and Harry Allen have all been let go as the club prepare for their first season outside the top flight since 2015-16.