The 2016 UB Bulls Football schedule has been finalized with MAC opponents:
| Game | Date | Opponent | Stadium | Location |
| 1 | Saturday, September 03, 2016 | vs Albany | UB Stadium | Amherst, NY |
| 2 | Saturday, September 10, 2016 | BYE | ||
| 3 | Saturday, September 17, 2016 | at Nevada | Mackay Stadium | Reno, NV |
| 4 | Saturday, September 24, 2016 | vs Army | UB Stadium | Amherst, NY |
| 5 | Saturday, October 01, 2016 | at Boston College | Alumni Stadium | Chestnut Hill, MA |
| 6 | Saturday, October 08, 2016 | vs Kent State | UB Stadium | Amherst, NY |
| 7 | Saturday, October 15, 2016 | vs Ball State | UB Stadium | Amherst, NY |
| 8 | Saturday, October 22, 2016 | at NIU | Huskie Stadium | DeKalb, IL |
| 9 | Thursday, October 27, 2016 | vs Akron | UB Stadium | Amherst, NY |
| 10 | Thursday, November 03, 2016 | at Ohio | Peden Stadium | Athens, OH |
| 11 | Saturday, November 12, 2016 | vs Miami | UB Stadium | Amherst, NY |
| 12 | Saturday, November 19, 2016 | at WMU | Waldo Stadium | Kalamazoo, MI |
| 13 | Friday, November 25, 2016 | at BGSU | Doyt Perry Stadium | Bowling Green, OH |
The good: A lot of early games at home.