Reggie Bush is the 23rd player from the 2006 NFL Draft to spend time on the Bills roster. Here's a ranking of the other 22.
With the signing of Reggie Bush to fill the roles of backup running back and return specialist, the Buffalo Bills have now employed 23 players who heard their names called during the 2006 NFL Draft, including each of the first three overall picks and seven of the first 32.
Nine of those players were picked by the Bills, while the rest have rotated in and out over the years. Few of them have had any meaningful impact, but a couple have been major contributors for a time.