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The Best Buffalo Bills players to wear 21-25

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22 Nov 1998: Running back Antowain Smith #23 of the Buffalo Bills in action during the game against the Indianapolis Colts at the Bills Stadium in Orchard Park, New York. The Bills defeated the Colts 34-11. Mandatory Credit: Rick Stewart /Allsport

The Best Buffalo Bills players to wear 21-25 are dominated by running backs.

Our fifth installment of the best Buffalo Bills players by jersey number continues with numbers 21-25. We nearly had a clean sweep of numbers by running backs, and I guess when given the number territory it’s expected. Some of these were so close to each other, just a few hundred yards or small differences in their stats made the difference in who got chosen.