6:40 p.m. ET | CBS
Matchup rating: 92.3 | Spread: KC -3 (53.5)
What to watch for: The Chiefs' run game will be something to keep an eye on. Kansas City rushed for a season-high 245 yards against Buffalo in Week 6, when the Bills played their safeties deep on many snaps and were determined not to let Tyreek Hill and other receivers beat them deep. They will certainly change strategies this time, but at what cost, especially now that quarterback Patrick Mahomes has cleared the NFL's concussion protocol?