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Five San Francisco 49ers to watch against the Buffalo Bills

The Buffalo Bills and the San Francisco 49ers face off on Monday Night Football this week. It’s the 13th meeting between the two clubs, and the third time they’ve met in primetime. Buffalo has lost both previous primetime games—a 27-17 heartbreaker in 1995 that turned on a Darrick Holmes goal-line fumble returned by Lee Woodall for a touchdown, and a 35-0 drubbing in 2001 when the 1-9 Bills were overmatched by the 8-2 49ers.

This time, it’s Buffalo with the superior record, as the 8-3 Bills look to make it three-for-four against the NFC West by beating the 5-6 49ers.