8:20 p.m. ET | NBC
Matchup rating: 82.1 | Spread: BUF -1.5 (48)
What to watch for: Over the past four weeks, the Bills own the second-best passing offense in the NFL in terms of yards per game. But the Steelers have allowed the third-fewest passing yards per game in that span. Considering Buffalo's struggles to run the ball effectively this season, it's critical the Bills either figure out a way to solve Pittsburgh's pass defense or get their run game going. -- Marcel Louis-Jacques
Bold prediction: James Washington will lead Pittsburgh receivers in targets.