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Fansided · Sep 11, 2021

Buffalo Bills vs. Pittsburgh: Final Score Prediction for Week 1 matchup

Dec 15, 2019; Pittsburgh, PA, USA; Pittsburgh Steelers head coach Mike Tomlin (left) and Buffalo Bills head coach Sean McDermott (right) greet each other after the game at Heinz Field. Buffalo won 17-10. Mandatory Credit: Charles LeClaire-USA TODAY Sports

The Buffalo Bills will open their 2021 season against the Pittsburgh Steelers. The Steelers are coming off a 2020 campaign in which they faltered down the stretch, losing five of their last six games.

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