The Buffalo Bills enter the NFL season as the outright betting favorite for the first time since 1991, as the franchise continues to pursue its first-ever Super Bowl title. The Bills are listed at +600 at Caesars Sportsbook ahead of their season opener Thursday against the defending champion Los Angeles Rams.
"We really think the Bills are the highest power-rated team, but just as importantly is where they play," SuperBook executive director and oddsmaker John Murray told ESPN. "The philosophy is the AFC West teams will beat each other up and that will allow the Bills to be in a favorable position to have the AFC Championship Game running through Buffalo.