October 4, 2020; Santa Clara, California, USA; San Francisco 49ers defensive end Kerry Hyder (92) during the second quarter against the Philadelphia Eagles at Levi's Stadium. Mandatory Credit: Kyle Terada-USA TODAY Sports
These are four players on the San Francisco 49ers that the Buffalo Bills should be concerned about the most.
For the second straight week, the Buffalo Bills are taking on a team with a record below .500. However, similar to the Los Angeles Chargers, the Bills can’t take the 49ers lightly. This is a team that is coming off a trip to the Super Bowl and one that has been hit hard by injuries this season.