The Buffalo Bills enter the 2022 NFL season as the Super Bowl favorites in Las Vegas, and the Bills will have plenty of chances to show why thanks to a schedule that features a league-high five primetime games, with the possibility for more.
They open the season on Thursday Night Football against the defending Super Bowl champion Los Angeles Rams, then host the Tennessee Titans in Week 2 on Monday Night Football for the home opener.
Buffalo also welcomes Aaron Rodgers and the Green Bay Packers to Buffalo for a Week 8 Sunday Night Football clash, travels to the Detroit Lions on Thanksgiving in Week 12, and plays on Monday Night Football in Week 17 against the defending AFC champion Cincinnati Bengals.