With the conclusion of the 2021 NFL regular season, the Buffalo Bills’ 2022 opponents are also set. In addition to their normal slate of home and away games against the AFC East, Buffalo will play the AFC North and the NFC North in 2022.
The NFL’s 17th game is an inter-conference matchup. After playing the NFC East in 2021, Buffalo’s opponent is the same-seeded team from the NFC West in 2022.
The Bills finished in first place in the division, so they will play three additional first-place teams; one each from the AFC West (away), AFC South (home), and NFC West (away).