West Ham's Andre Ayew could be out until Christmas with the thigh injury sustained in Monday's match at Chelsea.
Sofiane Feghouli, Aaron Cresswell and Manuel Lanzini are also sidelined but new signing Jonathan Calleri could make his Premier League debut.
Bournemouth manager Eddie Howe is unlikely to make sweeping changes from the side beaten by Manchester United.
There could be a debut for new recruit Marc Wilson but Junior Stanislas and Tyrone Mings are still injured.
MOTD COMMENTATOR'S NOTES
Steve Wilson: "West Ham's London Stadium (a venue waiting for naming rights to be sold if ever there was one) becomes the 55th ground to host Premier League football - and the third largest.